Celiac Disease Lab Tests May 2015

This month's blog is about gluten sensitivity and celiac disease. One of the primary studies that is often quoted I think is misleading. In this study by Fasano, he found that about 1:100 people checked with a particular blood test (a tissue transglutaminase antibody) had a positive reaction and were therefore described as having celiac disease. Previous studies had noted that a very high percentage of people with notable damage on intestinal biopsy looking for celiac disease were also positive for this enzyme antibody test.

The problem, I believe is that testing one antibody to a particular enzyme is not that definitive of a test. The assumption is that everyone who tests negative to that antibody is not gluten sensitive or in this case does not have celiac disease.

Cyrex Labs agrees and that is why they test 24 different gluten related antibodies including 4 different transglutaminase antibodies. We don't have hard numbers yet about the percentage of people who react to one or more of these antibodies, but our own clinical experience indicates that gluten is a force to be reckoned with. We don't test a true cross section of people but work with people trying to solve a particular health problem such as Hashimoto's, IBS, chronic anemia, general fatigue and other similar issues. In this population, I think we have had one or two people test negative for these antibodies. This leads us to conclude that gluten sensitivity, whether celiac or non-celiac gluten sensitivity is a factor in a high percentage of cases of chronic illnesses, especially autoimmune problems.

Many, many people choose to ignore this type of information. From conversations with these folks, I think it comes down to a couple of factors. One is that a portion of the gliadin molecule of the gluten protein complex is a stimulator of the opiate receptors in the brain causing a certain level of addiction. Addicts don't appreciate hearing that one of their favorite chemicals is causing them problems.

Also it takes effort to follow a strict gluten free diet. You have to be careful about which isles you shop at the grocery store, which restaurants you choose for your lunch and at the restaurant you will have to ask about the gluten status of the items.

If you are dealing with a chronic problem, some testing will be in order. We can send test kits to California and Nevada. Those of you in other states will have to hunt around for a doc who can run a Cyrex Labs Array 3. If you are testing a child, you might want to look at the antigliadin antibody tests by Enterolab (stool test).

If you are gluten sensitive, you probably also have methylation problems. Some supplements that we recommend helping with that are: EuroMedica Clinical Glutathione & BetterGenix NAC, links below!